Aprima (Apremilast), generic Otezla is a prescription medicine used to treat psoriatic arthritis (a condition that causes joint pain and swelling and scales on the skin). Apremilast used to treat also for plaque psoriasis. Aprima manufactured by Incepta Pharma Ltd. in Bangladesh.

To reduce risk of gastrointestinal symptoms, titrate to recommended dose of Aprima 30 mg twice daily according to the following schedule:

Day 1: 10 mg in morning
Day 2: 10 mg in morning and 10 mg in evening
Day 3: 10 mg in morning and 20 mg in evening
Day 4: 20 mg in morning and 20 mg in evening
Day 5: 20 mg in morning and 30 mg in evening
Day 6 and thereafter: 30 mg twice daily

Apremilast can be administered without regard to meals. 

Dosage adjustment in patients with severe renal impairment:

Apremilast dosage should be reduced to 30 mg once daily in patients with severe renal impairment. For initial dosage titration, it is recommended that Aprima be titrated using only the morning schedule and the evening doses be skipped.

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